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 Wysłany: Czw 7:17, 17 Mar 2011 Temat postu: tory burch outlet bpb wkc kljg juh |
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Recent second-generation evaluation of calcium antagonists
llenGSetal: NEnglJMed1983, 308:619 [8] OelmersHJ: AcreNeurolScand1984, 69:232 [9TakataYetal: Arzneim-Forsch1986, 36 (II): l464 [10] OpieLH: CardiovascDrugsTber1988, 2 (2): {94 [1I] DanielsAN. etal: AmJCardiol1987, 60:703 [12] KiowskiWetal: ibid1987, 59:1118 [133LepiraBetal: EurJClinPhaxmacol986, 29:523 [1lI. FagamTCetal: JCardiovascPharmacal1984, 6: S1109 [15] LjungB: Drugs1985, ~ (Supp12): 46 [16] AbergHetal: Drugs1985, 29fSuppl2): 117 [17] TaylorSHetal: AmJCardiol1987, 59: l23B [】 8] FaulknerJKetal: BrJGlinPharmacol1986, Z2 : 21 [19] LeePetal: CardiovascDrugsTh1987: I: 261. G0] FrickiV [H: CardiovascDrugsTher1987; 1:238 E2]] KhurmiNSetal: AmJCardiol1984,[link widoczny dla zalogowanych], 53:684 [22] RaschackM: EurHeartJ1984, 5:10 [23] KatoRetal: AmHeartJ1986, 111:27 I [2 students] Pflugfelderpwetal: AmJGardiol1987759: 1283G5] FrishmanWHetal: AmJCardiol1985, 55:43 [263BayerRetal: JMolCellCardiol1987: 19 (SupplIII): S4 [27] ShibutaSetal: JPharmacolExpThor1987. z40: l6 calcium channel blockers such as elderly patients with hypertension PiephoRW According to statistics, by 2000, 65 years old or older will account for more than 16 of the total world population. Under the current standards, more than equal to 160/95mmHg in patients with hypertension and older accounted for about half of the total. Common in elderly hypertensive patients with increased peripheral vascular resistance, blood volume and cardiac output trampling decreased cerebral and renal perfusion decreased. A substantial proportion of patients with left ventricular hypertrophy there, because the load increases heart ventricular ectopic occurs easily understood, and sudden death. The elderly and other major arteries of aortic vessel wall as the deposition of calcium and collagen gradually loses its elasticity, the middle wall of small blood vessels may be due to hyaline transformation leaving the lumen cross-sectional area and lumen / wall ratio reduced, these changes lead to with age-related hemodynamic changes,[link widoczny dla zalogowanych], resulting in increased peripheral vascular resistance. In recent years the clinical use of calcium channel blockers (CCB) has achieved good results in the treatment of hypertension. CCB drugs block the main role of calcium ions into smooth muscle cells, thus inhibiting a smooth muscle contraction and a reduction of 90 cells. Compared with diuretics and beta-blockers, CCB does not cause salt and fluid retention, or lead to biochemical abnormalities,[link widoczny dla zalogowanych], orthostatic hypotension and CNS dysfunction. For plasma renin activity (PRA) is low in elderly hypertensive patients, CCB still good effect. CCB drugs have on the multi-phase structure,[link widoczny dla zalogowanych], so that they meet the requirements of the clinical treatment of target. In addition, CCB fewer side effects,[link widoczny dla zalogowanych], interactions with other drugs, have less of these drugs are beneficial to the actual needs of elderly patients. A, CCB mechanism of a large number of studies show calcium in the mouth of an adrenergic vasoconstrictor tone mediated mechanisms play a leading role, CCB is able to block the vasoconstriction. CCB common mushrooms such as diltiazem, nifedipine and verapamil, certain anti-hypertensive effect of both, they have the same pharmacological effects and pharmacokinetic properties, such as short plasma half-sweet wine reduction and outside of medicine - - synthetic drugs, Shenghua Yao, preparation volumes
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