veoexrmpzt
Dołączył: 21 Lut 2011
Posty: 371
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Skąd: England
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 Wysłany: Sob 7:59, 05 Mar 2011 Temat postu: tory burch jcm ril nxrj ivj |
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,[link widoczny dla zalogowanych]
Abnormal coagulation and fibrinolysis in elderly hypertensive carotid artery atherosclerosis of
It promotes the release of inflammatory cells in certain cytokines such as interleukin-1,[link widoczny dla zalogowanych], increased endothelial cell synthesis and secretion, leading to PAI. 1 increased,[link widoczny dla zalogowanych], more emphasis on blood coagulation and thrombosis, atherosclerosis is a risk factor. PAI-1 is the endothelial cell extracellular matrix components, fibrinolytic system is the major inhibitory factors, recent research found that atherosclerotic plaques in the PAI1 activity increased, and PAI-1 increase in local regulation by the disease. When atherosclerotic vascular elevated local PAI-1, plasminogen activator as a fibrinolytic process blocked, leading to extracellular matrix accumulation and fibrin deposition, and promote plaque formation '. This study showed that elderly hypertensive patients with normal carotid artery, intimal thickening and plaque group plasma Dd, PAI-1 levels gradually increased, a significant difference, and the plasma D. d the level of plaque was significantly higher than in the group of intimal thickening, suggesting that D. d, PAI-1 levels and carotid atherosclerotic lesions is related to the body in patients with carotid artery plaque significantly hypercoagulable state and a fibrinolytic abnormalities. However,[link widoczny dla zalogowanych], plasma PAI-1 and intimal thickening in the plaque group and the control group, plasma D-d in the plaque compared with the control group there was no significant difference, consider the difference with a larger number of patients in each group related. This ruled out the selected object for the elderly hypertensive patients with diabetes, and blood lipids, blood pressure and age, no significant difference, but because of fewer cases, the patient's individual differences and laboratory operations and other factors, patients VwF, GMP a 140 and tPA levels in the normal carotid artery, intimal thickening and plaque 3, no significant difference between groups, their carotid artery atherosclerosis of further study. FIB, D-d, PAI-1 in carotid artery atherosclerosis, development and play an important role in plaque formation. Therefore, active antihypertensive treatment in patients with hypertension at the same time,[link widoczny dla zalogowanych], reducing fibrinogen, increased fibrinolytic activity, appropriate use of antiplatelet and antithrombotic therapy to prevent and delay the development of atherosclerosis and cardiovascular events is important significance.
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