veoexrmpzt
Dołączył: 21 Lut 2011
Posty: 371
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Skąd: England
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 Wysłany: Nie 17:31, 20 Mar 2011 Temat postu: tory burch flats pht gry qtdu faa |
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OPG / RANK / RANKL system and the regulation of bone metabolism
,[link widoczny dla zalogowanych], Morishima followed up the cases of no-reflow patients 3O 1.2 years, compared with the control group, no-reflow patients with malignant ventricular arrhythmias,[link widoczny dla zalogowanych], the incidence of left ventricular dysfunction and cardiovascular disease mortality is higher. And emergency PCI restore coronary blood before the blood of patients compared to normal, no-reflow in AMI patients prone to early failure, progressive left ventricular dilatation and remodeling, sustained no-reflow had higher mortality and re-infarction rate]. 2 Coronary no-reflow phenomenon no-reflow mechanism 803 with AMI coronary direct PCI and rotational vein graft lesions or peeled has a direct correlation between the treatment and its possible mechanisms are: plaque or plaque debris off small thrombus attached to the distal embolization feet off; the release of vasoactive substances in the loss of self-regulation microcirculation, microvascular sustained contraction,[link widoczny dla zalogowanych], decreased microcirculatory blood flow. The loss of microcirculation and microvascular autoregulation caused by the continued contraction of the mechanism of slow flow or no-reflow, calcium channel blockers verapamil or nicardipine effectively, but for thrombosis and embolism caused by slow flow or no-reflow drug treatment less effective. Despite the serious injury of microcirculation structure and function is one of the reasons no-reflow, but the exact mechanism of no-reflow is not clear, and its possible mechanisms: ① no-reflow regions of myocardial edema, capillary endothelial cell injury severe, localized to the luminal endothelial cells formed capillaries prominent cell embolization. ② myocardial edema and contraction of the lumen capillary pressure, blood flow decreased. ③ platelet and fibrin thrombus formation, the theoretical non-steroidal anti-inflammatory pain drugs, antiplatelet drugs and heparin, prostaglandin E can reduce the incidence of no-reflow. ④ cavity leukocyte microvascular thrombosis. ⑤ adhesion molecules and cytokine activation, animal experiments show that: AMI recovery after reperfusion, myocardial no-reflow region has a large number of adhesion molecule CD18 expression, and leukocyte adhesion molecules can CDI8 activation, adhesion, aggregation, leukocyte embolization. ⑥ IRA launched recovery after reperfusion increased the content of oxygen free radicals, oxygen free radicals in the formation of microvascular endothelial cells to increase cell damage embolism. White blood cells and endothelial cells thrombosis embolism formation of the microcirculatory blood flow decreased, resulting in the production of no-reflow. ⑦ microcirculation thrombosis, myocardial ischemia and recovery in the dog reperfusion animal models, Rochitte that: ischemic myocardial tissue microcirculatory blood flow refers to a serious decline in cardiac tissue in the region there is no-reflow phenomenon may be related to micro-circulation embolism related. The no-reflow by the pathophysiological process can be seen, no-reflow is caused by various factors involved in the formation. 3 Coronary no-reflow phenomenon no-reflow Although the clinical manifestations seen in the resumption of IRA recanalization of coronary reperfusion in the 19CapparelliC, KostenuikPJ, MoronyS, eta1. Osteoprote-gerinpreventsandreverseshypercalcemiainamurinemodelofhumoralhypercalcemiaofmalignancy [J]. CancerRas, 2000,[link widoczny dla zalogowanych],60:783 ~ 7872OBekkerPJ, HollowayD, NakanishiA,[link widoczny dla zalogowanych], eta1. Theeffectofasingledoseofosteoprotegerininpostmenopaulwomen [J]. JBoeMinnerRas, 2001,16 (2): 348 ~ 36021BodyJJ, greippP, eta1. AphaseIstudyofAMGN-0007, arecombinantosteoprotegerinconstruct, inpatientswithmultiplemyelomaorbreastcarcinomarelatedbonemetastasesI-J]. Cancer, 2003,97 (3): 887 ~ 89222BolonB, CabpagnuoloG, FeigeU. durationofboneprote-ctionbyasingleosteoprotegerininjectioninratswithadjuvant-inducedarthritis [J]. CellMolLifeSci, 2002,59 (9): 1569 ~ 1576
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