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 Wysłany: Śro 8:29, 30 Mar 2011 Temat postu: Lipo PGE1 patients with unstable angina pectoris a |
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Lipo PGE1 patients with unstable angina pectoris and the influence of blood rheology
rnalofChina-JapanFriendshipHospital,[link widoczny dla zalogowanych], 2003Oct, Vo1.17. No. 5295sT segment in> 0.1mV or sT segment returned to normal; effective: the extent and frequency of angina attacks decreased by 50% to 80%, ECG sT segment in 0.05-0.1mV or T wave dominated shallow Union> 50% converted to upright or flat; invalid: the process and reduce the number of angina attacks Measurement data using statistical methods 1.5 t test; count data for the X test. 2 Results The clinical efficacy and blood rheology results in Table 1,2. The clinical treatment group, total effective rate (97.0%) was significantly better than the control group (73.3%) (P <0.05), treatment group hemorheology indexes improvement rate (96.0%) also significantly better than the control group (76.0%) (P <0.05). 2 patients during treatment of vascular slight irritation, slight in 1 case of headache, infusion, 3 patients were not line special treatment, symptoms disappeared after stopping; no liver and kidney function, blood glucose, blood lipids and other indicators of significant change. Table 2 two groups of patients before and after the changes of hemorheology (x4-s) Note: before treatment,} P <O. 05;}} P <O. 01.3 uA discussion is between stable angina and acute myocardial infarction among a group of syndromes, such as the timely and effective treatment is not easy to develop into acute myocardial infarction and sudden death, uA conventional treatment method is Diffuser Nitroglycerin at the same time plus active anticoagulant, antiplatelet therapy, early use of antithrombotic treatment can mortality J. PGE has a variety of biological activity, can dilate blood vessels, reducing peripheral resistance, to improve the collateral circulation, in vivo, were significantly inhibited white blood cell and platelet activity J, and can inhibit platelet synthesis of thromboxane A:, against 5 to dilute hydroxy arachidonic acid, inhibition of vascular endothelial cells to produce nitric oxide and prostacyclin effect in that the prostacyclin / thromboxane A: balance J, to relieve angina pectoris, ischemic myocardial metabolism to promote, improve myocardial ischemia and improve blood flow viscosity. LipoPGE. Lipo is a targeted drug with conventional preparation of alprostadil compared with the following characteristics: targeting, sustainability, efficiency, low side effects and a high degree of security. This study shows that the total effective rate in treatment group was significantly higher. In particular, the efficacy of UABraunwaldm level in patients with more obvious in the treatment group were 15 cases of grade Ⅲ total effective rate was 100%. Hemorheology compare the two groups are also significant differences, particularly in high shear blood viscosity, blood viscosity, erythrocyte aggregation index, erythrocyte deformability and fibrinogen improvement is most obvious, with domestic Liu Zhao et al reported match. And the treatment group were not found in the treatment of bleeding, allergies and liver 'kidney dysfunction and other side effects and adverse reactions. In the conventional treatment based on the use LipoPGE treatment uA, simple, safe, treatment better. 4
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